Amy Winehouse is raised in a Jewish family, with her father Mitch and her grandmother Cynthia sharing their love for music and singing. Her friend Tyler hands a demo tape of Amy’s recording to his manager Nick, who is impressed by her talent. Amy signs a contract with Island Records and releases her debut album, Frank (2003).

After enjoying critical and commercial success, her record label suggests changes to her stage act before releasing Frank in the United States, which Amy strongly disagrees with. She announces she needs time off to “live her songs” and then meets Blake Fielder-Civil in a pub in Camden Town, where they fall in love. Their relationship is soon troubled by Blake’s cocaine addiction, Amy’s alcoholism, and bulimia. Blake reveals he thinks they would be better as friends and plans to reconcile with his ex-girlfriend Becky, leaving Amy heartbroken. Before traveling to New York City, she learns her grandmother has terminal lung cancer. During this difficult period, she gathers inspiration to write her second album, Back to Black (2006), which becomes a global success.

Blake and Amy reconcile shortly after the release of Back to Black. They elope to Miami, much to Mitch’s dismay. Soon afterwards, Blake is arrested for assaulting a pub landlord and serves a two-year sentence in jail for perverting the course of justice. Before he is released and as Amy has now become a drug addict, Blake tells her he has been undergoing counseling and asks her for a divorce, wanting a fresh start.

After various blackouts, Amy agrees to check into a rehabilitation center and later wins five Grammy Awards. Three years later at her new home on Camden Square, Amy is now clean of drugs and trying to tackle her alcohol dependence. After a visit from Mitch, the paparazzi reveal that Blake has a new girlfriend, Sarah, who has just had his baby. A tearful Amy sings “Tears Dry on Their Own” and walks up to her bedroom.

A postscript reveals that Amy was found dead at the age of 27 on July 23, 2011. Her untimely death was caused by alcohol poisoning after a long period of sobriety. She was laid to rest with her grandmother, Cynthia.